In the present study deals the simultaneous estimation of Hydralazine hydrochloride and Propranolol in combined tablet dosage form have been developed using Distilled water as a solvent. Two method is developed one is simultaneous equation method at 260 nm and 288 nm. The second is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 273 nm (isoabsorptive point) and at 288 nm the (maximum absorption of Propranolol). Beer’s law Obeyed in concentration range of 4-20 μg/ mL and 10-50 μg/ mL for Hydralazine Hydrochloride and Propranolol respectively. The accuracy of the methods was assessed by recovery studies was found to be 99.80±0.316 and 99.65±0.209 for simultaneous equation method and 99.86±0.556 and 99.55±0.856for Q analysis (absorption ratio) method for Hydralazine hydrochloride and Propranolol respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
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